Welcome to the Hodgson-Zingman Lab

Denice Hodgson-Zingman, MD, UIowa

My research focuses on cardiac metabolism, heart failure and arrhythmia mechanisms but also probes similarities between cardiac and skeletal muscle mechanisms that contribute to the overall balance of body metabolism.

Lab Members

Principal Investigator

Denice Hodgson-Zingman, MD
(Faculty Profile)

Research Specialist

Zhiyong Zhu

Assistant Research Scientist

Zhan Gao


Anna Sierra

Recent Publications

Sex-Specific Comparative Effectiveness of Oral Anticoagulants in Elderly Patients With Newly Diagnosed Atrial Fibrillation.
Palamaner Subash Shantha G, Bhave PD, Girotra S, Hodgson-Zingman D, Mazur A, Giudici M, Chrischilles E, Vaughan Sarrazin MS.
Circ Cardiovasc Qual Outcomes. 2017 Apr;10(4). pii: e003418. doi: 10.1161/CIRCOUTCOMES.116.003418.

Loss of ATP-Sensitive Potassium Channel Surface Expression in Heart Failure Underlies Dysregulation of Action Potential Duration and Myocardial Vulnerability to Injury.
Gao Z, Sierra A, Zhu Z, Koganti SR, Subbotina E, Maheshwari A, Anderson ME, Zingman LV, Hodgson-Zingman DM.
PLoS One. 2016 Mar 10;11(3):e0151337. doi: 10.1371/journal.pone.0151337. eCollection 2016.

Disruption of ATP-sensitive potassium channel function in skeletal muscles promotes production and secretion of musclin.
Sierra A, Subbotina E, Zhu Z, Gao Z, Koganti SR, Coetzee WA, Goldhamer DJ, Hodgson-Zingman DM, Zingman LV.
Biochem Biophys Res Commun. 2016 Feb 26;471(1):129-34. doi: 10.1016/j.bbrc.2016.01.166. Epub 2016 Jan 30.

Musclin is an activity-stimulated myokine that enhances physical endurance.
Subbotina E, Sierra A, Zhu Z, Gao Z, Koganti SR, Reyes S, Stepniak E, Walsh SA, Acevedo MR, Perez-Terzic CM, Hodgson-Zingman DM, Zingman LV.
Proc Natl Acad Sci U S A. 2015 Dec 29;112(52):16042-7. doi: 10.1073/pnas.1514250112. Epub 2015 Dec 14.

Morpholino-driven gene editing: A new horizon for disease treatment and prevention.
Subbotina E, Koganti SR, Hodgson-Zingman DM, Zingman LV.
Clin Pharmacol Ther. 2016 Jan;99(1):21-5. doi: 10.1002/cpt.276. Epub 2015 Nov 10. Review.

Venous Stenosis After Transvenous Lead Placement: A Study of Outcomes and Risk Factors in 212 Consecutive Patients.
Abu-El-Haija B, Bhave PD, Campbell DN, Mazur A, Hodgson-Zingman DM, Cotarlan V, Giudici MC.
J Am Heart Assoc. 2015 Jul 31;4(8):e001878. doi: 10.1161/JAHA.115.001878.

Disruption of KATP channel expression in skeletal muscle by targeted oligonucleotide delivery promotes activity-linked thermogenesis.
Koganti SR, Zhu Z, Subbotina E, Gao Z, Sierra A, Proenza M, Yang L, Alekseev A, Hodgson-Zingman D, Zingman L.
Mol Ther. 2015 Apr;23(4):707-16. doi: 10.1038/mt.2015.21. Epub 2015 Feb 4. Erratum in: Mol Ther. 2015 Nov;23(11):1794.

All publications